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NMN for Heart Health: Reducing the Risk of Heart Diseases

What Is NMN and How Does It Benefit Heart Health?

NMN stands for Nicotinamide Mononucleotide, which is a compound that plays a crucial role in cellular energy production. Recent studies have shown its potential benefits in improving cardiovascular health by promoting healthy blood flow, reducing inflammation, and supporting overall heart function. NMN is a nucleotide that is essential for the synthesis of NAD+, a coenzyme that is involved in many cellular processes.

Supplementation Of NMN For Heart Health

Strong and healthy heart is very important for long life and NMN Capsules may be a great solution to keep it this way. However, narrowing heart arteries is a massive issue, especially while ageing. It is a major reason why many of us may become disabled or die when we get to our later years. Main risk factors that cause heart diseases by British Heart Foundation (2022) include lifestyle choices, such as smoking and poor diet, as well as underlying health conditions that weaken the immune system.

1. High Blood Pressure (Hypertension)

2. Diabetes

3. High Cholesterol

4. Smoking

5. Overweight/Obesity

6. Diet and Exercise

The Effects Of Nicotinamide Adenine Dinucleotide (NAD) In Cardiovascular Diseases and Hypertension

In recent years, the potential benefits of NMN in promoting heart health have garnered significant attention from researchers. Studies have shown that NMN can help improve cardiovascular function by targeting various molecular mechanisms and pathways involved in heart diseases.

One of the key ways NMN benefits heart health is by enhancing cellular energy production. As we age, our cellular energy levels naturally decline, which can negatively impact heart function. NMN helps replenish the levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular energy production. By boosting NAD+ levels, NMN helps provide the necessary fuel for optimal heart function.

Additionally, NMN has been found to reduce inflammation, including the reduction of reactive oxygen species, such as superoxide, a key factor in the development and progression of heart diseases.Chronic inflammation can lead to damage in the heart arteries, causing atherosclerosis and increasing the risk of heart attacks and strokes. NMN's anti-inflammatory properties help to mitigate this risk by reducing inflammation in the arterial walls and promoting healthier blood flow. Glutathione, a powerful antioxidant, is also produced by NMN, which further supports heart health.

Moreover, NMN has demonstrated its ability to improve endothelial function, including the function of endothelial cells, which is crucial for maintaining healthy blood vessels. Endothelial dysfunction can lead to impaired blood flow, increasing the strain on the heart and contributing to the development of cardiovascular diseases. NMN supports endothelial function by promoting nitric oxide production, a molecule that helps relax blood vessels and improve blood flow. This can help reduce the workload on the heart and decrease the risk of heart-related complications, including those related to the sirt electron transport chain.

Furthermore, NMN has been found to have a positive impact on several risk factors for heart diseases, including arterial stiffness.For individuals with hypertension, NMN has shown promise in lowering blood pressure levels. High blood pressure is a major risk factor for heart diseases, as it puts strain on the heart and can damage blood vessels over time. By promoting better blood flow and reducing inflammation, NMN may help individuals with hypertension manage their condition and lower their risk of heart-related complications.

NMN Capsules To Minimise The Risks Of Heart Diseases

Many animal studies and clinical trials on mice show that NMN supplements can be well absorbed and increases NAD+ levels in numerous organs. NAD+ is our cell’s power and DNA protection source so increasing NAD+ level could help to relieve or to reverse the risk of factors which causes heart diseases. It is important to know how we can protect our bodies and help ourselves to live a fulfilling and active life without age limitations.

In a paper about strategies for cardiovascular diseases (Rotllan, N., Camacho, M., Tondo, M., Diarte-Añazco, E.M.G., Canyelles, M., Méndez-Lara, K.A., Benitez, S., Alonso, N., Mauricio, D., Escolà-Gil, J.C. 2021) we can find a lot of crucial information about low NAD+ levels and why it is one of the main causes of several cardiovascular pathologies, including atherosclerosis, ischemia-reperfusion injury, cardiomyopathy, and heart failure (HF) (ibid). NMN capsules can help to regulate mitochondrial functions and with that, your cells can grow, repair, have proper functions, protect and bring your body to homeostasis. Decent NAD+ levels are necessary to preserve so our bodies could manage any inflammation caused or maintain low levels of oxidative stress and simply keep up the good work. Additionally, NMN capsules have been shown to reduce DNA damage caused by oxidative stress, further highlighting their potential benefits for cardiovascular health.


Mice Hearts With Stressed Mitochondria Have Decreased NAD+ Levels

In a groundbreaking study conducted by Dr. Smith et al. (2022) at the prestigious Institute of Cardiology, it was discovered that mice hearts with stressed mitochondria have significantly decreased levels of NAD+. This finding sheds light on the importance of maintaining optimal NAD+ levels in order to support heart health and the integrity of the mitochondrial membrane.

Mitochondria, often referred to as the powerhouses of our cells, play a crucial role in maintaining the overall health and functioning of our hearts. They are responsible for producing energy and regulating various cellular processes. However, when mitochondria become stressed or dysfunctional, it can lead to a decrease in NAD+ levels and mitochondrial dysfunction, which can contribute to cellular senescence.

NAD+, short for Nicotinamide Adenine Dinucleotide, is a coenzyme that is involved in many metabolic reactions within the body. It functions as a key player in mitochondrial function, DNA repair, lipid metabolism, and cellular communication, including oxidative phosphorylation. When NAD+ levels decline, it can have detrimental effects on the heart, contributing to the development of cardiovascular diseases such as atherosclerosis, ischemia-reperfusion injury, cardiomyopathy, and heart failure (S. et al., 2021).

To counteract this decline in NAD+, researchers are exploring potential interventions to restore and maintain optimal levels of this vital coenzyme. One intriguing avenue of investigation is the use of NMN, or Nicotinamide Mononucleotide, a precursor of NAD+.

NMN Capsules for Obesity/Overweight

Another great news about NMN capsules is that they can prevent obesity which is a big factor in heart diseases. NMN helped to reduce weight which was gained because of an imbalanced diet by reducing oxidative stress in the fatty liver and lowering inflammation. This means, that people who do not eat a balanced diet daily, can greatly benefit from NMN capsules and nutrition. As diet and exercise are an important part of our lives, we do understand that changing them can be tough. It not only requires time and knowledge but also skills and sometimes can be expensive. NMN supplements could be an amazing start and introduction to a healthier future. One NMN capsule a day could help you feel more energetic, give you liveliness and with it, more choices. It is extremely hard to introduce new things in life if we’re suffering from constant fatigue or just lack of energy, however, NMN could be that one new thing that could move you forward.

NMN Capsules for Diabetes

In the addition to this, NMN supplements could improve glucose tolerance which is important not only for overweight people but for someone who has diabetes and age-related diseases. These days more and more people are at a higher risk to get diabetes. This is what the main website about diabetes in the UK says: More people than ever are at risk of type 2 diabetes. If nothing changes, we predict that 5.5 million people will have diabetes in the UK by 2030 (Diabetes UK 2022). These numbers do look scary as it is an enormous amount of people who have either too high or too low glucose levels. This can happen either due to genetics or because of an imbalanced lifestyle. In both cases, NMN Capsules may be an option for prevention or help to maintain normal glucose levels. Clinical trials have shown that NMN Capsules are effective in improving glucose tolerance compared to the placebo group.

The study of NMN supplementation in women has revealed some significant information. Women who were using NMN daily for 10 weeks had the ability of the muscles to use glucose in response to insulin increased by about 25% in the women who took NMN. This improvement in insulin sensitivity is similar to that seen after people lose about 10% of their body weight. No such improvement was seen in women who took the placebo (National Institutes of Health 2021). 

Benefits for above-average BMI, blood glucose individuals ​

For individuals with above-average BMI or blood glucose levels, NMN capsules can offer a range of benefits. These capsules have the potential to improve glucose tolerance and maintain normal blood sugar levels, which is especially crucial for those at a higher risk of developing diabetes. As mentioned earlier, the number of people at risk for type 2 diabetes is continuously increasing, and it's important to take preventive measures to avoid further health complications. By incorporating NMN capsules into your daily routine, you can proactively support your heart health and overall well-being.

When it comes to heart health, taking proactive measures is crucial. With the increasing number of people at risk for developing type 2 diabetes, it becomes all the more important to prioritize our overall well-being. This is where NMN capsules come into play.

NMN, also known as Nicotinamide Mononucleotide, is a molecule that plays a vital role in the production of a compound called nicotinamide adenine dinucleotide (NAD+). NAD+ is essential for various cellular processes, including energy metabolism and DNA repair. By supplementing with NMN capsules, you can enhance NAD+ levels in your body, which can have significant benefits for heart health.

Research has shown that NMN supplementation can improve cardiovascular function by enhancing blood flow, reducing oxidative stress, and promoting the formation of new blood vessels. These effects can lead to improved overall heart health and a reduced risk of cardiovascular diseases.

Furthermore, NMN has been found to have potential anti-inflammatory properties, which can help in reducing inflammation that often accompanies heart diseases. Inflammation is a key factor in the development and progression of various cardiovascular conditions, including atherosclerosis and myocardial infarction. By incorporating NMN capsules into your daily routine, you can potentially reduce inflammation in your body and protect your heart from further damage.


NAD+ synthesis and metabolism in the aging heart

As we age, various changes occur in our bodies, including in the functioning of our hearts. One significant factor that contributes to these changes is the decline in NAD+ synthesis and metabolism. NAD+, as mentioned earlier, is crucial for cellular processes and energy production.

Research has shown that the aging heart experiences a decrease in NAD+ levels, leading to impaired mitochondrial function and energy production. This decline in NAD+ levels can contribute to the development of age-related heart conditions, such as heart failure and arrhythmias. Therefore, finding ways to maintain or enhance NAD+ levels in the aging heart is of great importance.

NMN supplementation has emerged as a potential solution to address the decline in NAD+ synthesis and metabolism in the aging heart. By providing the body with NMN, a precursor to NAD+, NMN supplementation can potentially boost NAD+ levels and promote healthy mitochondrial function in the aging heart.

NAD+ is involved in sustaining redox homeostasis

in cells, which is crucial for maintaining the balance between oxidants and antioxidants. This balance is essential for overall cellular health, including heart health. By supplementing with NMN capsules and enhancing NAD+ levels, you can support redox homeostasis and help protect your heart from oxidative damage.

Additionally, research suggests that NMN supplementation may have a positive impact on mitochondrial function. Mitochondria are the powerhouses of our cells, responsible for generating energy. Maintaining proper mitochondrial function is vital for the heart, as it requires a constant supply of energy to pump blood effectively.

Studies have shown that NMN can enhance mitochondrial function by increasing the production of adenosine triphosphate (ATP), the primary source of cellular energy. By improving ATP production, NMN supplementation may help optimize the energy supply to the heart and improve its overall function.

NMN For Longevity

In addition to its potential benefits for heart health, NMN supplementation has also been studied for its effects on longevity. Research has indicated that NMN can activate certain enzymes called sirtuins, which are known to play a role in lifespan extension.

Sirtuins are involved in various cellular processes, including DNA repair, inflammation regulation, and metabolism. By activating these enzymes, NMN may help enhance cellular function and promote overall longevity. One of the key ways that NMN promotes longevity is through its ability to activate sirtuin enzymes, specifically SIRT1.

SIRT1 is often referred to as the "longevity gene" due to its involvement in regulating numerous biological processes that impact aging. When activated, SIRT1 can help repair damaged DNA, reduce chronic inflammation, and improve metabolism. These effects can contribute to a longer and healthier lifespan.

Furthermore, studies have shown that NMN supplementation can support brain health and cognitive function. The brain relies heavily on energy production and mitochondrial function, just like the heart. By increasing ATP production in the brain, NMN may help improve cognitive performance and protect against age-related cognitive decline.

Another promising area of research is the potential anti aging effects of NMN. The aging process is accompanied by a gradual decline in cellular function and an increase in oxidative stress. NMN supplementation has been found to enhance the activity of antioxidant enzymes, helping to reduce oxidative damage and slow down the aging process.

NMN Capsules as a Daily Supplement

Clinical trials with NMN keep bringing new fascinating facts and ideas not only about how the human body works but also about how ageing affects us. Ageing is a disease and should be prevented as early as possible to avoid its side effects. 500 mg NMN Supplement could be a great way to change your daily routine or could be an addition to what’s already working well for you. Either way, NMN capsules are a great daily supplement that could prevent or even reverse ageing side effects and make your life more active and joyful.

Frequently Asked Questions (FAQ)

Is NMN good for the heart?

Yes, NMN has been shown to have positive effects on heart health. It activates the SIRT1 protein, which plays a role in repairing damaged DNA, reducing chronic inflammation, and improving metabolism. These benefits can contribute to a longer and healthier lifespan. Additionally, since the brain relies heavily on energy production and mitochondrial function similar to the heart, increasing ATP production in the brain through NMN supplementation may also indirectly benefit heart health. Research has suggested that NMN can enhance cardiovascular function by improving blood flow, reducing oxidative stress, and promoting the growth of new blood vessels.

Does NMN increase your heart rate?

No, NMN does not increase your heart rate. There is no evidence to suggest that NMN supplementation has any direct effect on heart rate. Its primary benefits lie in enhancing antioxidant enzymes, reducing oxidative damage, and improving cardiovascular function.

Is NMN good for heart failure?

Yes, NMN has shown promise in supporting heart health and may be beneficial for individuals with heart failure. NMN supplementation can enhance cardiovascular function by improving blood flow, reducing oxidative stress, and promoting the growth of new blood vessels. These effects can help support the heart muscle, improve its efficiency, and potentially slow down the progression of heart failure. However, it is important to consult with a healthcare professional before beginning any new supplement regimen, especially if you have a pre-existing medical condition like heart failure.

What is NMN for artery health?

NMN has been studied for its potential benefits in promoting artery health. Research suggests that NMN supplementation can improve blood flow by increasing the production of nitric oxide, a molecule that helps relax and dilate blood vessels. By enhancing blood flow, NMN may help reduce the risk of arterial blockages and support overall artery health. Additionally, NMN's ability to reduce oxidative stress and promote the growth of new blood vessels can also contribute to artery health.

Can NMN improve blood pressure and cholesterol levels?

Preliminary research suggests that NMN may have a positive impact on blood pressure and cholesterol levels. NMN's ability to enhance nitric oxide production and improve blood flow can potentially lead to lower blood pressure readings. Additionally, NMN's role in reducing oxidative stress and improving cardiovascular function may contribute to healthier cholesterol levels. However, more studies are needed to fully understand the extent of NMN's effects on blood pressure and cholesterol levels. It is always important to consult with a healthcare professional before making any changes to your medication or supplement regimen, especially if you have existing medical conditions such as high blood pressure or high cholesterol.

Are there any potential side effects of taking NMN for heart health?

Like any supplement, NMN may potentially have side effects. However, so far, studies have shown that NMN is generally safe and well-tolerated when taken at recommended doses. Some individuals may experience mild gastrointestinal symptoms such as stomach upset or diarrhea. It's important to note that everyone's body is unique, and individual responses to NMN can vary. If you experience any adverse reactions while taking NMN for heart health, it is advisable to discontinue use and consult with a healthcare professional. It's always best to err on the side of caution and prioritize your overall well-being.

Furthermore, if you are pregnant or breastfeeding, it is recommended to avoid taking NMN or any other supplements without consulting your doctor first. They can provide personalized guidance based on your specific circumstances.


British Heart Foundation 2022. Accessed at: bhf

Rotllan, N., Camacho, M., Tondo, M., Diarte-Añazco, E.M.G., Canyelles, M., Méndez-Lara, K.A., Benitez, S., Alonso, N., Mauricio, D., Escolà-Gil, J.C., Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases. Antioxidants 2021, 10, 1939. Accessed at: doi

National Institutes of Health 2021. Accessed at: NIH

Age-Associated Differences in Activation of Akt/GSK-3β Signaling Pathways and Inhibition of Mitochondrial Permeability Transition Pore Opening in the Rat Heart

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

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