All of us, at some point, were feeling exhausted after a tough day at work when we could barely lift our feet to walk and all we wanted to do was fall on our favourite couch or bed, get a warm cup of tea or a glass of cold water, keep legs straight and watch some TV shows without anyone disturbing us. Some of us wake up feeling like this. The exhaustion is real and back or knee pain or a headache doesn't help and the whole day may seem like the toughest quest. Science is moving forward and in the near future, we may feel less of this and more happiness to move without getting tired instantly while we're getting older. Getting older is now considered to be a disease and the World Health Organisation (WHO) added ageing to the International Classification of Diseases list back in 2018. (Shade C., 2020) Thanks to NMN and the science of anti-ageing that he promotes, we can prolong our lifespan and also improve the quality of life without diseases! NMN is known to play an essential role in energy metabolism. It is a key regulator of metabolism and aging.

It has been seen to increase energy production and metabolic fitness while protecting against age-related diseases like heart disease and diabetes. In this blog, we’ll discuss all things NMN: what it is, its benefits, side effects and dosage.

What Is NMN (Nicotinamide mononucleotide)?

It is thought that NMN supplement is only a chemical compound made by scientists to prolong life, however, NMN can naturally be found in such vegetables as avocados, broccoli, cabbage, edamame and cucumbers (ibid). The issue with Nicotinamide mononucleotide in vegetables and fruits is that it contains only a tiny amount of NMN and it's not enough for our bodies to feel a difference.

NMNsify NMN capsules are synthesized from vitamin B3 and while tested by a 3rd party Laboratory, are confirmed as a safe anti-ageing booster for anyone over 28. Studies with mice suggest that young mice are less responsive to this longevity booster than older ones, however, more clinical trials with humans are needed (ibid).

How Does Pure NMN Supplement Work?

NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme in our metabolism. NAD+ can be found in all living cells on our planet and what's important to know is that NAD+ levels drop almost by half when we reach our 50s. Here comes the NMN. Once we use NMN capsules, they are absorbed and either converted to NR (nicotinamide riboside) or directly transported across the cell membranes and converted to NAD+ (ibid). This is where all the benefits start. NMN is great for DNA repair and DNA protection. Still, many contemplate, why people are choosing NMN instead of NR. The answer is that NMN is more similar to NAD+, it is more stable than NR, better absorbed and more clinical trials are done with pure NMN than NR. 

Why Do We Need To Increase NAD+ Levels With Supplement NMN?

As we have mentioned before, while getting older, our NAD+ levels drop, but why do we need to increase them again? Before starting to use pure NMN, we must know what happens if we do not use them.

Shin-ichiro Imai one of the best-known MD, and PhD professors in ageing and longevity studies in mammals that Dr Sinclair often refers to 'has said that NMN may improve adult human metabolism, rendering it more like that of someone ten or twenty years younger' (ibid).

His words show that age-related drop in NAD+ could cause issues with metabolism, furthermore, the other article from 'The National Library of Medicine states that 'Decline in NAD+ availability and abnormal NAD+/NADH redox state are tightly linked to age-related metabolic diseases and neurodegenerative disorders (Zhu XH, Lu M., Lee BY, Ugurbil K., Chen W., 2015).

All this can suggest that if we don’t use NMN supplementation in later years, NAD+ levels drop our body gets weaker, and the metabolic rate gets lower. We start to gain more weight and with this our blood sugar and blood pressure increase causing more and more dangerous diseases.

NMN Supplement Benefits and Longevity

David Sinclair a Ph.D. scientist in Biology and Harvard University lecturer is probably the best-known longevity promoter. He has said that using NMN supplement with the correct diet has improved his life already and 'his blood markers, at nearly 60 years old, are closer to those of a 31-year-old' (Shade C., 2020). This clearly indicates, that increasing NAD+ can prevent many unwanted age-related symptoms because it helps with DNA repair.

Possible Supplement Benefits

• Endurance to your skeletal muscles
• Improved fitness levels
• Lower risk of heart diseases
• Improved insulin sensitivity
• Improved eye function
• Lower chances of age-related weight gain
• Could protect the nervous system
• Improve cognition
• Could help to fight obesity and metabolic disorders

It can also be a great ally in helping to reduce alzheimer’s disease side effects. Unfortunately, some of the benefits (ibid) still lack studies on humans (Wang et al., 2016), but NMN Supplement is getting more popular and more funding goes towards longevity.

NMN Supplement Side Effects

Some people report that using NMN in higher doses may make them feel nauseous, may cause diarrhoea or some tummy discomfort, or they may not sleep at night due to too much energy, however, human trials with up to 1200mg (Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T., 2022) have shown that it was safe and didn't cause any side effects. There are no known significant or dangerous side effects from 3rd Party tested and safe brands.

The biggest issue is with unsafe and untested NMN brands. They are usually cheaper in price, sadly, many of these brands offer either low quality or no NMN in the capsule at all. Please, be careful and choose only tested brands like NMNsify for your supplement needs. All our products have the highest quality on the market and every batch is tested by an independent 3rd Party Lab.

Does NMN Cause Cancer?

As we have mentioned before,  NMN supplements do not have any significant negative side effects. Cancer is a very sensitive theme and we need to be sure that anything we take does not encourage the growth of cancer cells. In clinical trials with mice that had lung cancer a team of experienced Chinese scientist have revealed that NMN neither promote nor suppress cancer or other tumour growth (Pan F., Kang S., Zhao Y., Dai L., Shao Q., Yang Y., Chen Q., Zhu J., Cut L. 2020). This news is great and gives some assurance that NMN will not cause or increase the risk for such a seriously life-changing, challenging and unfortunately, in many cases deadly illness. 

How Much NMN Supplement Should I Take?

David Sinclair's supplements list can be found on Google, he has reported on the Joe Rogan podcast, that he uses 700mg-1000mg NMN supplement daily (Rogan J., 2019)

This dosage is pretty high and we would suggest starting lower.

• For people from 28 to 35 years, NMN 500 mg capsule in the morning on an empty stomach would be the best choice and should offer enough benefits.
• From 36 to 55 years NMN 500 mg 2 capsules would be a great choice. Again, try to use it on an empty stomach for the best results.
• Over 56 we would suggest increasing your dosage to 1 - 2 mg daily or two- four NMN 500 mg capsules.

NMN Dosage Suggestion

These are only general suggestions for NMN supplements and if you feel that you need to lower or increase your dosage do it carefully and gradually as we have mentioned before, due to high energy levels you may not fall asleep easily. Do not forget to talk with your doctor as they know you well and could help you to decide the best dosage. This information is meant to help and add to your knowledge, not replace advice from your doctor and is not meant to cover all possible uses, precautions, interactions or adverse effects. This supplement is a great addition to healthy aging.

How to Take NMN Supplements?

This supplement is absorbed best if taken on an empty stomach. You can use water or any other drink that you like, but we would suggest avoiding coffee. As David Sinclair mentioned in a Joe Rogan podcast (ibid), he only drinks one cup of coffee in the morning and only drinks tea afterwards. NMN and coffee could be a bit too much if someone is more sensitive and may result in a slightly higher pulse than usual. Most people do not feel the difference, but anecdotal feedback may indicate such an effect. We would also suggest taking it as early as possible because some people have reported that if they take this longevity booster later in the day, they have too much energy and can’t get sleep as easily as they usually do.

How Long Does It Take For NMN to Start Working

NMN is absorbed within minutes and gets into your bloodstream in around 15-30 minutes (Mills K. F., Yoshida S., Stein L. R., Grozio A., Kubota S., Sasaki Y., Redpath P., Migaud M. E., Apte R. S., Uchida K., Yoshino J., Imai S. 2017), so you should feel the difference within your first use of NMN supplement. The longer you use it, the more different kinds of benefits you will notice. If you do not feel the difference, try adjusting the dosage first by increasing it. Do not trust companies who advertise that you should feel the difference only after 1-2 weeks. NMN energy boost should be felt from day 1 if the dosage is right for you. 

NMN Boosts Energy Metabolism

NMN supplement is a great way to boost energy metabolism and increase cellular function. NMN, or nicotinamide mononucleotide, is a molecule that plays a key role in energy metabolism. It works by increasing the levels of NAD+ in the body, which is an important coenzyme involved in cellular energy production. By boosting NAD+ levels, NMN can improve mitochondrial function and enhance metabolism, leading to increased energy levels and improved overall health. In addition, NMN has been shown to have anti-aging effects and may help protect against age-related metabolic disorders such as diabetes and obesity.

Conclusion

NMN is considered a safe supplement that does not have significantly dangerous side effects. We do need more clinical trials with humans to know more details and what other benefits it has to offer, but so far NMN has brought new colours and more energy to numerous lives. Ageing can be challenging, but now we have a chance to make a difference and to live longer without limitations. 

In short, NMN is a promising anti-aging strategy that deserves your attention. It might not be the fountain of youth, but it can help you age gracefully and improve your general health in the process. The benefits of NMN supplementation include better sleep, reduced oxidative stress, improved metabolism, and enhanced fat metabolism. Be sure to consult your doctor before starting a new supplement. They can tell you if you’re healthy enough to start taking it or if there are any possible interactions with other medications or supplements you’re taking.

  

Frequently Asked Questions

What are the benefits of using NMN supplement?

NMN, or nicotinamide mononucleotide, is a naturally occurring compound found in both plants and animals. It has been linked to potential health benefits such as anti-aging effects, energy-boosting effects, cognitive improvements, reduced inflammation, and protection from free-radical damage.

Taking NMN supplements may help slow down the aging process by boosting levels of NAD+, a molecule that helps cells repair themselves and maintain a healthy balance of metabolic processes. This can lead to better energy levels, improved cognitive function, and better overall health.

In addition, a longevity booster can provide protection from free radical damage as well as reduce inflammation levels in the body. This can help reduce the risk of certain diseases such as cancer, Alzheimer's disease, heart disease, and diabetes.

Finally, NMN supplements may also help improve metabolic functioning and promote healthy weight management. They can boost the body’s metabolic rate which can help burn fat more efficiently leading to successful weight loss.

How long should I take NMN supplement before seeing results?

Taking NMN supplementation should be part of a healthy lifestyle, so it's important to monitor changes in your body while taking the supplement. The effects of these longevity boosters are typically felt after the first capsule, with an energy boost that is impossible to miss.

However, results will vary from person to person, so it is best to monitor any changes in energy levels, cognitive function and physical performance for at least two weeks before deciding if this energy booster is working for you. If you find yourself feeling more energized, alert, and stronger than usual, then NMN supplementation could benefit you. On the other hand, if you don’t feel any significant differences in energy levels or performance then it’s best to explore other supplements or strategies.

What is NMN supplement?

NMN stands for nicotinamide mononucleotide, which is an organic compound found naturally in your body. NMN has become a popular supplement because of its potential anti-aging and health-promoting benefits. It may be beneficial for increasing energy levels, improving muscle and cognitive function, and reducing inflammation.

It's important to note that there is still limited research on the effects of NMN supplements and the long-term effects are unknown. Therefore, it's important to speak to your doctor provider before taking any new supplement, including NMN, as it may interact with other medications or treatments you are taking.

Does the NMN supplement really work?

The efficacy of NMN as a dietary supplement is still being studied by researchers. Some studies have indicated that NMN may help to slow down aging and increase energy levels in the body, but more research is needed to confirm these effects. Additionally, the effects of NMN on different medical conditions are still unknown, so it is best to seek advice from your healthcare provider before taking any form of supplementation.

Is NMN worth taking?

NMN (Nicotinamide mononucleotide) is a naturally occurring compound found in foods like broccoli, cabbage, and avocados. It has been studied for its potential anti-aging, energy-boosting, and cognitive benefits.

Studies have shown that NMN may help improve blood glucose levels, reduce inflammation, and promote longevity. However, the effects of NMN are still being studied and more research is needed to determine its effectiveness.

Ultimately, whether or not NMN is worth taking is up to you. Make sure to talk to your doctor before taking any supplement to ensure it’s safe for you and that it won’t interact with any other medications you’re taking.

What are the side effects of taking NMN?

NMN stands for nicotinamide mononucleotide and is a natural-occurring precursor of nicotinamide adenine dinucleotide (NAD) in our bodies. It is a coenzyme involved in the metabolism of energy and it has been studied for its potential health benefits on aging, metabolism, and longevity.

However, like any other supplement, there are some side effects associated with taking NMN. Common side effects of taking NMN include stomach upset, headache, nausea, dizziness, and drowsiness. It can also interact with certain medications, including blood pressure medications and insulin-related drugs. Therefore it is important to consult with a doctor before beginning any supplementation. Additionally, NMN supplements should not be taken during pregnancy or while breastfeeding.

What age should you start taking NMN?

NMN (Nicotinamide mononucleotide) is not recommended for people under 18 years of age. Even though NMN is a natural supplement, it can still have side effects in certain individuals, so you should always consult with your doctor before taking NMN to make sure that it is safe for you. Furthermore, if you are taking any medications, check with your doctor to see if they may interact with NMN or not. As with most supplements, it's best to start slow and increase dosage gradually if needed.

Is NMN supplement safe?

The short answer is yes, this longevity booster is generally considered safe when taken as directed. However, it is important to make sure that you are purchasing NMN supplements from a reputable source like NMNsify. Additionally, NMN may cause certain side effects such as stomach upset, nausea, and diarrhea. If you have any existing medical conditions or are taking other medications, make sure to talk to your doctor before taking NMN supplement. All in all, this longevity booster may be beneficial for some people but always make sure to do your research.

How can I use NMN supplement to lose weight and keep it off?

NMN (nicotinamide mononucleotide) supplementation may be a useful tool in your weight loss journey. NMN has been shown to help boost energy levels, which can help you stay active and burn more calories as you move throughout the day. Additionally, NMN is also known to help improve metabolic functions, such as regulating blood sugar levels, and metabolism of fat, which helps your body naturally regulate its weight.

By supplementing with NMN and combining it with a healthy diet and regular exercise, you can increase your chances of achieving and maintaining a healthy weight.

 

References:

Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022; 14(4):755. doi

Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. NCBI

Pan F., Kang S., Zhao Y., Dai L., Shao Q., Yang Y., Chen Q., Zhu J., Cut L. ‘Effect of β-nicotinamide mononucleotide on tumor formation and growth in a lung cancer mouse model’ Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai with University of Shanghai for Science & Technology, Shanghai 2020 doi

Rogan J., ‘The Joe Rogan Experience’, #1234-David Sinclair. Spotify

Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integr Med (Encinitas). 2020;19(1):12-14. ncbi

Xiaonan Wang, Wuejun Hu, Yang Yang, Toshihiro Takata, Takashi Sakurai. Nicotinamide mononucleotide protects against ß-a myloid oligomer-induced cognitive impairment and neuronal death. Brain Res, 2016; DOI: 10.1016 / j.brainres.2016.04.060 shokou-lifetech

Zhu XH, Lu M, Lee BY, Ugurbil K, Chen W. In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2876-81. doi: 10.1073/pnas.1417921112. Epub 2015 Feb 17. PMID: 25730862; PMCID: PMC4352772. ncbi