What Is The Best Anti-Aging Supplement That Works?

NMN, NR, and NAD are some of the best anti-aging supplements that have shown promising results. They work by supporting cellular health and boosting energy production in the body.

Effective Supplement For Anti Aging?

NMN (Nicotinamide Mononucleotide) is considered one of the most effective anti-aging supplements. It helps boost NAD+ levels in the body, which play a crucial role in energy production and cellular repair. NMN has been shown to improve metabolism, increase longevity, and enhance overall health and well-being.

What is NMN?

Nicotinamide mononucleotide (NMN) is a molecule found in fruits, vegetables, beef and shrimp. NMN is primarily located in the cell’s nucleus, mitochondria and cytoplasm of every living creature and when tested can be found in placenta tissue, blood and urine (Nadeeshani, H., Li, J., Ying, T., Zhang, B. and Lu, J., 2021). It is a Nicotinamide adenine dinucleotide (NAD+) precursor, meaning that once our body absorbs NMN it can be transformed into NAD+. It is important to note that NMN and NAD+ work closely together to metabolise energy in our cells, meaning it is the power source of our bodies. Without NMN and NAD+ we wouldn’t exist, which is one of the reasons why NMN is called longevity or an anti-ageing supplement (Ratajczak, J., Joffraud, M., Trammell, S., 2016). NMN has been shown to reduce wrinkles and improve skin elasticity in animal studies, making it a promising anti-aging supplement for humans as well as a potential treatment for oxidative stress.

What is NR?

Nicotinamide Riboside (NR) is a molecule that can naturally be found in milk and some vegetables.  Same as NMN it is also one of the NAD+ precursors. However, NR needs to be converted to NMN by the NRK enzyme before converting to NAD+, while NMN is the immediate precursor (ibid). NR, like NMN, is a crucial component in the production of NAD+. It serves as a precursor to NAD+ and plays a vital role in maintaining the energy balance within our cells. While NR can be found naturally in certain foods, its availability may not always be sufficient to meet our body's demands, especially for calcium absorption. This is where supplementation with capsules comes into play.

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a molecule that is crucial in many metabolic processes, including the maintenance of telomere length. For example, it is responsible for DNA repair or even our lifespan extension and more (Lin S. J., Guarente L., 2003). Unfortunately, the older we get the more NAD+ levels to fall. Low NAD+ levels can have serious consequences, DNA damage, less energy, and a higher risk for diseases to name just a few. As we age, our bodies undergo various changes, one of which is a decline in NAD+ levels. Nicotinamide adenine dinucleotide (NAD+) is a molecule that plays a vital role in numerous metabolic processes, including DNA repair and lifespan extension. However, as mentioned earlier, as we grow older, our NAD+ levels naturally decrease.

NMN Supplement Benefits

The benefits of NMN supplementation are vast and promising for healthy aging. By increasing NAD+ levels in the body, NMN can help improve cellular energy production, enhance mitochondrial function, and support overall metabolic health. Studies have shown that NMN may have anti-aging effects, boosting lifespan and improving age-related decline in various tissues. Additionally, NMN has been linked to improved cardiovascular health, brain function, and cognitive abilities. It has also shown potential in reducing inflammation, enhancing muscle function, and promoting weight loss by stimulating collagen production.

NR Supplement Benefits

There are fewer clinical trials with NR compared to NMN, but from studies done, we can see that NR has slightly different benefits than NMN. In this recent study published in 2022, we can see that Nicotinamide Riboside positively affects and boosts brain and central nervous system activity and reduces inflammation in the brain, which is an essential benefit in older age (Brakedal B., Dölle C., Riemer F., Ma Y., Nido G. S., Skeie G. O., Craven A. R., Schwarzlmüller T., Brekke N., Diab J., Sverkeli L., Skjeie V., Varhaug K., Tysnes O. B., Peng S., Haugarvoll K.). Reducing inflammation in the brain may reduce the chances of Alzheimer’s disease and even Dementia and can help keep our minds clearer and focused for longer.

Furthermore, NR showed some good results in lowering blood pressure while increasing energy, which is beneficial for individuals at risk of heart disease, especially in older age (Martens, C.R., Denman, B.A., Mazzo, M.R., 2018).

NMN vs. NR, Which Is Better?

When it comes to comparing the best anti-aging supplements like NMN and NR, it's important to understand that both supplements have their unique benefits. NMN has been extensively studied for its potential to improve cellular energy production, enhance mitochondrial function, and support overall metabolic health, including the immune system, especially for older people. These effects are crucial for combating the aging process and promoting longevity. Research has also shown that NMN may have positive impacts on cardiovascular health, brain function, cognitive enhancement, muscle endurance, and antioxidants.

On the other hand, NR has its own set of advantages. As mentioned earlier, it has been found to positively affect brain and central nervous system activity, reducing inflammation in the brain and improving cognition. This is particularly beneficial for older individuals as it may decrease the risk of Alzheimer's disease and dementia while helping maintain clarity and focus. Additionally, NR has been shown to support immune function, making it a valuable supplement for overall health.

Another noteworthy benefit of NR is its potential to lower blood pressure and increase energy levels, as well as regulate blood sugar. This is especially beneficial for those who have higher than-usual blood pressure as they age. By reducing inflammation in the body and improving cardiovascular health, NR can contribute to a healthier and more active lifestyle in older adults. A systematic review of studies has shown that NR supplementation can improve blood pressure, energy levels, and blood sugar regulation in older adults.

So, which supplement is better? It ultimately depends on the specific goals and needs of each individual. If someone is primarily concerned about cellular energy production, mitochondrial function, and overall metabolic health, NMN may be the better choice. However, NMN can also boost cognitive function and is more versatile than NR, making it a potential option for those concerned about cognitive decline.

NMN side effects

While NMN is generally considered safe for consumption, some potential side effects have been reported, including gastrointestinal discomforts such as nausea, diarrhea, and abdominal pain. However, it's important to note that these side effects are rare and typically mild, and taking NMN may also reduce the risk of heart disease.

NR side effects

Similarly to NMN, NR is generally considered safe for consumption with few reported side effects. Some individuals may experience mild gastrointestinal discomforts, such as nausea or diarrhea, but these occurrences are rare and usually temporary. However, it is important to note that taking high doses of NR may lead to an increased risk of adverse effects on immunity, including an increased risk of infections such as iu. It is always recommended to consult with a healthcare professional before starting any new supplement regimen.

NMN or NR to boost NAD+ levels?

As both of these supplements are precursors to NAD+, it is thought that they may affect different parts of the bodily tissues. It certainly needs more clinical trials, but it is thought that NMN may boost energy and aerobic capacity more and NR may boost brain activity, however, this is not proven. 

Overall, the NMN supplement is thought to be a better one as its molecule is closer to the NAD+. Another thing with NR is that it is not as stable in the blood as NMN is, so it is harder to measure NR levels in the human body, compared with NMN. Also, more clinical trials are done with NMN, so we can feel safer and know more about how it affects our body and how this NAD+ precursor can help us to improve heart health.

We would suggest not trusting NMN and NR creams yet, as information that NMN and NR can’t break the skin barrier is clear and scientists are still working on particular technologies to create creams that could help with skin hydration and allow NMN to pass through our skin barrier and be absorbed in such a way.

Conclusion

Both, NMN and NR are safe to use and can offer great benefits and a strong addition to a daily routine. Improved memory, better performance in sports, more energy and much more can help a great deal in changing bad old habits to new, healthy ones. 

 Frequently Asked Questions (FAQ)

What is the best supplement to look younger?

The best supplement to look younger is subjective and may vary from person to person. However, when it comes to anti-aging, NMN (Nicotinamide Mononucleotide) is thought to be a promising option. NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), which plays a crucial role in energy production and cellular repair. By boosting NAD+ levels, NMN may help improve various aspects of aging, such as skin elasticity, muscle function, and cognitive performance. Its molecular structure closely resembles NAD+, making it more efficient in converting into this essential coenzyme.

Can an anti-aging supplement also help with other health issues besides aging?

Yes, an anti-aging supplement can potentially have additional health benefits besides addressing the signs of aging. NMN, for example, has been studied for its potential role in improving overall health. By boosting NAD+ levels, NMN may help enhance cellular function and repair, which can have a positive impact on various health issues. Some studies suggest that NMN may support cardiovascular health, metabolic function, and even brain function. However, it is important to note that further research is still needed to fully understand the extent of these potential benefits.

Is NMN Safe To Use?

NMN is generally considered safe for most individuals when used as directed. It is a naturally occurring compound found in small amounts in certain foods and also produced by the body. Many studies have been conducted on animals and human cells, which have shown promising results regarding the safety of NMN supplementation. However, more controlled clinical trials are still needed to confirm its safety and efficacy in humans. It is important to consult with a healthcare professional before starting any new supplement regimen, especially if you have any underlying medical conditions or are taking medications. They can provide personalized guidance based on your specific health situation and help determine whether NMN supplementation is right for you.

Is NR Safe To Use?

NR (nicotinamide riboside) is another compound that has gained attention for its potential anti-aging benefits. Like NMN, NR is a precursor to NAD+ and may help boost cellular function and repair. When used as directed, NR is generally considered safe for most individuals. It is also naturally present in some foods and produced by the body. However, it is important to note that more research is needed to fully understand the safety and efficacy of NR supplementation in humans. While studies have shown promising results in animals and human cells, controlled clinical trials are still necessary to confirm its benefits and potential side effects.

 

References:

Brakedal B., Dölle C., Riemer F., Ma Y., Nido G. S., Skeie G. O., Craven A. R., Schwarzlmüller T., Brekke N., Diab J., Sverkeli L., Skjeie V., Varhaug K., Tysnes O. B., Peng S., Haugarvoll K., et al. The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease. Cell Metabolism, Elsevier Inc. 2022. Accessed at: doi.

Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. 

Lin S. J., Guarente L., Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease, Current Opinion in Cell Biology, Volume 15, Issue 2, 2003, Pages 241-246, ISSN 0955-0674, doi.

Martens, C.R., Denman, B.A., Mazzo, M.R. et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 9, 1286 (2018). Accessed at: doi.

Nadeeshani, H., Li, J., Ying, T., Zhang, B. and Lu, J., 2021. Nicotinamide mononucleotide (NMN) as an anti-aging health product–promises and safety concerns. Journal of Advanced Research. Accessed at: Science direct

Ratajczak, J., Joffraud, M., Trammell, S. et al. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun 7, 13103 (2016). Accessed at: doi

Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. NCBI